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AI +  iHTS™  Display

Highest affinity and unprecedented diversity
Maximize your R&D success in the AI era.

We transform your reference antibody into 10 experimentally validated candidates with world leading binding affinities in just 2 months.

Maximum affinities possible in the industry with the broadest sequence diversity to strengthen your IP moat

The AI +  iHTS™ DBTL Cycle

An exhaustive, non-cherry-picked approach to discover the absolute best variants for your target.

1. Design

AI-powered library design using proprietary antibody protein language models + AlphaFold3 to generate 10,000+ diverse, patent-distinct variants optimized from your reference antibody.

2. Build

Automated high-throughput library construction and packaging into our proprietary fully automatic  iHTS™ display system.

3. Test

We do not “pick” clones. Instead we perform exhaustive screening of every clone in the entire phage library. This guarantees true comprehensiveness, maximum diversity, and the best affinity improvements — followed by BLI validation with full binding curves and exact KD values.

4. Learn

All experimental data from thousands of screened variants feeds back into our AI models.

How to Start Collaborating

A streamlined, frictionless process from sequence to validated candidates.

1

We can be reached through email or phone and will get back to you right away. Once we understand your needs, we will be able to generate solutions for you. After that we get started.

2

This is the equivalent of running thousands of experiments in parallel to find the best characteristics for your mab. We call this our Design Build Test Learn loop approach, which is an approach we validated with many leading companies to precision engineer the best possible final sequences.

3

These are all patent-distinct sequences + complete BLI data.

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Why Trust Us

Built for pharma and biotech leaders who demand the best data

The best of both worlds

AI/precision engineering + Physical production + BLI testing — actual data delivered

Patent-Safe Space

10,000+ novel variants while preserving epitope.

Superior Performance

On average, our campaigns generate dramatically more coverage and affinity gains

Complete Data Package

Full BLI sensorgrams + affinity values for all 10 final sequences

Unique Platform

Only Fidelis integrates AI language models + AlphaFold3 + automatic iHTS™

Proven Speed

Reliable 2-month delivery with updates.

Our Track Record

Our team has worked successfully with all major pharmaceutical, biotechnology companies, and academic institutions on antibody development, as well as academic institutions.

Insights & Updates

Stay ahead in antibody development

Read the Case studies.

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